4B Technologies and Peking University Third Hospital Announce Strategic Collaboration to Co-Develop Therapeutic Solutions for ALS

        近日,专注神经系统创新药研发新锐——福贝生物与国内渐冻症顶级权威临床诊疗机构——北京大学第三医院(北医三院),就开展“肌萎缩侧索硬化症(ALS)联合研发”签署战略合作协议。双方将整合各自资源与优势,紧密合作,在ALS疾病领域开展转化医学和药物开发方面的合作研究,着力打造新型的国际化临床研究和药物开发平台。

        肌萎缩侧索硬化症(ALS)是一种由运动神经细胞进行性退化引起的快速进展性神经退行性疾病,多数患者生存期一般只有3-5年,是WHO认定的世界五大绝症之一,迄今为止尚无有效治疗方式。近年来ALS的发病率仍在全球范围内持续增长,迫切需要新药和新疗法快速推进到临床阶段,为广大患者带来福音。ALS是医学研究领域的一大难题,也是福贝生物创新药研发的聚焦点之一。此前福贝生物已在ALS新药研发方面建立了从治疗理念、管线、转化到临床的系统战略和布局,基于不同的机理开发出多条ALS新药管线。

        此次福贝生物与北医三院签署的战略合作将围绕ALS疾病治疗相关的靶点发现、转化和逆向转化、临床研究、科研交流平台建设等方面开展,旨在充分利用北医三院樊东升教授团队在ALS临床医学方面的国内引领地位、创新能力和临床资源,结合福贝生物的前沿技术平台,新药研发团队长期深耕在神经系统疾病领域的创新药物研发经验,端对端的新药创新研发能力,在此框架协议的指导下,共同合作推进具有全球转化潜力的研究项目,源源不断地开发出能解决临床尚未满足需求的新的临床治疗手段,最终使患者临床获益,造福人类。

福贝生物CEO管小明博士表示:

        北医三院拥有中国最大规模的ALS诊疗/研究中心、全世界最大的单中心ALS临床数据库、原创的ALS肌电图新技术,是国内ALS诊疗领域最权威的医疗机构。这次很荣幸能与北医三院达成战略合作,本次签约将在前期诸多交流与合作的基础上,全方位加强双方在临床研究领域的战略合作,建立创新协作机制、增进双方学术和技术交流,积极探索创新的合作落地模式,实质性地提高原创新药开发的成功率。

关于北京大学第三医院

        北京大学第三医院成立于1958年,目前是国家卫生健康委旗下的,集医疗、教学、科研、预防保健、康复与健康管理为一体的综合性三甲医院,已跻身国内三甲医院第一方阵。北医三院拥有神经内科、眼科等20个国家临床重点专科,建有神经退行性疾病生物标志物研究及转化北京市重点实验室,拥有中国最大规模的ALS诊疗/研究中心,建成了全世界最大的单中心ALS临床数据库、患者登记注册队列(超过3000例)和生物样本库;原创性开发用于临床早期诊断、鉴别诊断和病情评估的肌电图新技术,有关结果被收录于高等医学院校《神经病学》教科书及国内最新颁布的诊断标准;在国内首先建立了用于ALS患者早期认知障碍筛查的方法;建立了具有代表性的中国罕见病研究/诊疗中心、以及研究/诊疗人员培训体系,作为牵头单位发起和组织了亚太国家ALS国际联合研究项目;引领中国ALS临床研究领域。

关于福贝生物

        福贝生物是一家致力于开发治疗神经系统重大疾病原创新药的生物高科技公司(www.4btechnologies.com),由著名神经科学家、清华大学教授鲁白博士和GSK前研发副总裁管小明博士创立,其愿景是将科学创想转化为切实的患者受益,凭借对致病机理的深入理解,通过颠覆性技术和新颖运作模式,提升创新药物研发效率,满足患者未被满足的医疗需求。目前福贝在苏州、上海和北京建立了早期研发、临床前和临床研究中心。公司聚焦神经营养因子信号通路和神经炎症作用机理,致力于开发原创性抗体和小分子药物,用于治疗神经退行性疾病如肌萎缩侧索硬化症(ALS),阿尔茨海默症(AD);脑血管疾病如脑卒中;神经功能疾病如慢性疼痛,等多种具有巨大未满足需求,对国计民生有重大影响的神经系统疾病。


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